Innovation & Research

Publications List

Delafloxacin: Activity against Fastidious Organisms Tested by EUCAST vs CLSI Methodology

asm microbe 2018 Atlanta June 7-11, 2018.

CD205-Shuttle Study: a first in human trial of Men1309/OBT076 an ADC targeting CD205 in solid tumor and NHL

Asco Annual Meeting 2018 Chicago June 1-5,2018

Translational model-based approach to the dose-range selection of an antibody-drug conjugate entering Phase I.

Page twenty-seventy meeting, 29 May-1June, 2018.

The role of MEN1611, a class I PI3-kinase (PI3K) inhibitor, in reprogramming the pro-tumoral inflammatory environment.

AACR Annual Meeting 2018, Chicago April 1-5,2018

MEN1611, a novel a-selective PI3K inhibitor in solid tumors

AACR Annual Meeting 2018, Chicago April 1-5,2018

Influence of a Combination of Chemical Enhancers and Iontophoresis on In Vitro Transungual Permeation of Nystatin

AAPS PharmSciTech Feb 1-8, 2018.

DNA topoisomerase-mediated transcription-replication conflicts cause DNA damage by a transient increase of R loops and proteasome activity

Molecular Cancer Therapeutics 2018 Jan 17:1 S1.

Correction: Dexketoprofen/tramadol 25 mg/75 mg: Randomised double-blind trial in moderate-to-severe acute pain after abdominal hysterectomy

BMC Anesthesiology 2017 Nov 17:1.

The neurokinin-2 receptor antagonist ibodutant improves overall symptoms, abdominal pain and stool pattern in female patients in a phase II study of diarrhoea-predominant IBS

Gut 2017 Aug 66(8):1403-1413.

Tramadol hydrochloride 75 mg/dexketoprofen 25 mg oral fixed-dose combination in moderate-to-severe acute pain: Sustained analgesic effect over a 56-h period in the postoperative setting.

Drugs of Today 2017 Jun; 53(6): 339-347

CD205, a target antigen for a novel antibody drug conjugate (ADC): Evaluation of antigen expression on non-Hodgkin lymphoma (NHL).

ASCO Annual Meeting 2017, Chicago June 2-4, 2017. e14039

Characterization of the novel antibody drug conjugate MEN1309 and its target antigen Ly75

AACR Annual Meeting-2017, Washington DC, April 1-5, 2017

The novel anti-CD205 Antibody Drug Conjugate (ADC) MEN1309 shows strong antitumoral activity in diffuse large B cell lymphoma (DLBCL).

AACR Annual Meeting-2017, Washington DC, April 1-5, 2017

MEN1309, a novel antibody drug conjugate (ADC) targeting Ly75 antigen, induces complete responses in several xenografts of solid tumors.

AACR Annual Meeting-2017, Washington DC, April 1-5, 2017

Impact of Rescue Medication on Pain Intensity Assessment: the result of two randomised double-blind trials to evaluate Dexketoprofen/Tramadol 25mg/75mg on moderate to severe acute pain post major surgery

International Association for the Study of Pain (IASP), 30 September 2016

Dexketoprofen-Tramadol 25mg/75mg in post-operative moderate to severe pain: the analgesic effect (measured as % of maximum SPID) in comparison with dexketoprofen 25 mg and tramadol 100 mg

International Association for the Study of Pain (IASP), 30 September 2016

Pain management following total hip replacement: Reporting on the DAVID-ART experience with dexketoprofen in combination with tramadol

European Orthopaedic Research Society (EORS) Congress, 14-16 September 2016

The antagonist profile of ibodutant at the tachykinin NK(2) receptor in human colon appeared gender-and agonist-dependent

Neurogastroenterology and Motility 2016 Aug; 28 S1 (37).

Changes of excitatory and inhibitory neurotransmitters in the colon of rats underwent to the wrap partial restraint stress

Neurogastroenterology and Motility 2016 Aug; 28(8):1172-1185.

Structure-Activity Study of the Peptides P5U and Urantide by the Development of Analogues Containing Uncoded Amino Acids at Position 9

ChemMedChem. 2016 Aug 19;11(16):1856-64.

A pilot study on the incidence of severe photosensitivity reactions leading to hospitalization linked to topical ketoprofen and other medications in selected European regions

Pharmacology Research and Perspectives 2016 Jun 4(3): 1-9.

Gender related differential effect of tachykinin NK2 receptor-mediated visceral hyperalgesia in guinea pig colon.

Br J Pharmacol. 2016 Apr;173(8):1329-1338.

Proteomic screening identifies calreticulin as a miR-27a direct target repressing MHC class I cell surface exposure in colorectal cancer.

Cell Death Dis. 2016 Feb 25;7:e2120

Randomized clinical trial of dexketoprofen/tramadol 25mg/75mg in moderate-to-severe pain after total hip arthroplasty.

Febuxostat pharmacokinetic/pharmacodynamic bridging from adults to pediatrics for effective prophylaxis of tumor lysis syndrome: from Florence to Floret study

57th ASH Annual Meeting, Orlando FL, December 5-8 2015

MEN1112/OBT357, an Anti Bst1/CD157 Humanized Antibody Inducing Acute Myelogenous Leukemia (AML) Blast Depletion in an Autologous Ex Vivo Assay: A Potential New Targeted Therapy for AML

57th ASH Annual Meeting, Orlando FL, December 5-8 2015

A Double-Blind, Randomized, Controlled, Four Parallel Arm, Dose-Finding Study to Evaluate the Efficacy, Safety, Tolerability,and Pharmacokinetics of Single Intra-Articular (lA) Injections of Fasitibant in Patients with Symptomatic OA of the Knee.

ACR/ARHP Annual Meeting, 6-11 Nov 2015

Efficacy of oral ibodutant in ibs-d female patients measured by urgency score: an iris-2 exploratory analysis

UEGW 2015, 24-28 Oct

Febuxostat a new weapon in armamentarium of tumor lysis syndrome management: results of Florence pivotal study.

XVII Congresso Nazionale AIOM - Roma 23-28 Oct 2015

Enhanced Ca(2+) response and stimulation of prostaglandin release by the bradykinin B2 receptor in human retinal pigment epithelial cells primed with proinflammatory cytokines

Biochem Pharmacol. 2015 Sep 15;97(2):189-202.

DEX-TRA-05: Randomised clinical trial to evaluate an oral dexketoprofen/tramadol combination for treatment of moderate-to-severe acute pain after total hip arthroplasty.

9th Congress of the European Pain Federation (EFIC), September 2-5, 2015 Vienna (Austria).

Pooled data of randomised trials on dexketoprofen/tramadol to evaluate the analgesic efficacy on moderate-to-severe acute pain: 8-hour TOTPAR.

9th Congress of the European Pain Federation (EFIC), September 2-5, 2015 Vienna (Austria).

DEX-TRA-04: Randomised double-blind trial to evaluate dexketoprofen/tramadol 25mg/75mg oral fixed combination on moderate-to-severe acute pain after abdominal hysterectomy.

9th Congress of the European Pain Federation (EFIC), September 2-5, 2015 Vienna (Austria).

Dexketoprofen/tramadol combination analgesic efficacy evaluated through the use of rescue medication in comparison of dexketoprofen, tramadol, and placebo.

9th Congress of the European Pain Federation (EFIC), September 2-5, 2015 Vienna (Austria).

Analgesic efficacy of dexketoprofen/tramadol versus dexketoprofen, tramadol, and placebo: analyses by pain response rate

9th Congress of the European Pain Federation (EFIC), September 2-5, 2015 Vienna (Austria).

Population Exposure-Response Modeling Of Oral Nepadutant Administration In Infants With Colic

12th Congress EACPT - Madrid 27-30 June 2015. Abstract published in "Clinical Therapeutics Journal", Volume: 37 Issue 8 e115, August 01, 2015

FLORENCE:A Randomized, Double-blind, Phase III Pivotal Study of Febuxostat Versus Allopurinol for the Prevention of Tumor Lysis Syndrome (TLS) in Patients with Hematologic Malignancies at Intermediate to High TLS Risk

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Pharmacokinetics Of Dexketoprofen And Tramadol Given In Combination: An Open-Label, Randomized, 3-Period Crossover Study In Healthy Subjects.

12th Congress EACPT - Madrid 27-30 June 2015 Published in "Clinical Therapeutics Journal", Volume: 37 Issue 8 e124, August 01, 2015

MEN1112/OBT357: Targeting BST1/CD157 Antigen With A Humanized, Defucosylated Antibody: A Novel, Approach Against Acute Myeloid Leukemia

WIN 2015 Symposium, Amphi theatre, 3rd Floor, Hotel Novotel Tour Eiffel. Paris, France ( Jun 2015)

European Union (EU) vs Non-EU (NOEU) Countries study compliance: the experience of the phase III FLORENCE study testing febuxostat in the Tumor Lysis Syndrome (TLS) prevention.

2015 ASCO Annual Meeting - J Clin Oncol 33:5s, 2015 (suppl; abstr e20677), 29 May - 2 June 2015

“ARMY”: First –in-Human Study of the Humanized, Defucosylated Monoclonal Antibody (mAb) MEN1112/OBT357 targeting CD157 antigen, in Relapsed or Refractory (R/R) Acute Myeloid Leukemia (AML)

ASCO Annual Meeting 2015 - J Clin Oncol 33:5s, 2015 (suppl; abstr TPS3100), 29 May-2 June

Missing data for repeated measures: single imputation vs multiple imputation and their implications on statistical significance.

PharmaSUG 2015 – Orlando, 17-20 May 2015

Efficacy of Oral Ibodutant in IBS-D Female Patients Measured by Abdominal Pain Severity An IRIS 2 Post-Hoc Analysis

DDW2015-Washington DC, USA 16-19 May-Su1160- Gastroenterology , Volume 148 , Issue 4 , S-491

Assessment of IBS-D severity: a case study from Two Randomized, Double-Blind, Placebo Controlled Pivotal Trials to Evaluate the Efficacy of Oral Ibodutant

DDW2015 –Washington DC, USA 16-19 May-Su1160 -Gastroenterology - , Volume 148 , Issue 4 , S-490 -S491

A Randomized, Double-Blind, Placebo-Controlled Phase II Study to Evaluate the Efficacy of 7 Days of Orally Administered Nepadutant in Infants with Colic- the NO-CRY Study

DDW 2015 –Washington DC, USA 16-19 May-Su1160 -Gastroenterology, Vol. 148, Issue 4, S-423–S-424

The No-Cry Study: A Randomised, Double Blind, Placebo Controlled, Pilot Study Assessing The Efficacy Of Nepadutant In Infant Colic

ESPGHAN 2015 –Amsterdam (NL), 6-9 May, 2015

The Response Rate After Single and Repeated Doses of Nepadutant as Symptomatic Treatment of Infant Colic: the NO-CRY Phase II Clinical Trial.

Benzofused hydroxamic acids: useful fragments for the preparation of histone deacetylase inhibitors. Part 2: 7-fluorobenzothiophenes and benzofurans

Bioorg Med Chem Lett. 2015 Apr 1;25(7):1603-6

Ranolazine Reduces The Late Recurrences Of Atrial Fibrillation An Exploratory Analysis Of The Raffaello Study

AHA 2014 Chicago, USA 15-19 Nov 2014

The IRIS project on Ibodutant: Clinical development of a new, first-in-class innovative agent for the treatment of Irritable Bowel Syndrome (IBS)

Basic & Clinical Pharmacology &Toxicology, 115. Suppl.3; 20-47. October 2014

Lead optimization of P5U and urantide: discovery of novel potent ligands at the urotensin-II receptor

J Med Chem. 2014 Jul 24;57(14):5965-74.

A randomized double-blind phase III pivotal study of febuxostat (FEB) versus allopurinol (ALL) in the prevention of tumor lysis syndrome (TLS): Florence study.

ASCO Annual Meeting - J Clin Oncol 32:5s, 2014 (suppl; abstr 9641), 13 May 2014

Concordance Among Outcome Variables Assessing the Response to Treatment With Ibodutant in Irritable Bowel Syndrome With Diarrhea (IBS-D; the IRIS-2 Study)

Gastroenterology, May 2014 Volume 146, Issue 5, Supplement 1, Page S-194

Serum biomarkers clusters improve the detection of symptomatic treatment effect in knee osteoarthitis patients: the results of a phase ib/iia with the b2 receptor antagonist fasitibant

OARSI 2014- 24-27 Apr

Handling with missing data in clinical trials for time-to-event variables.

PharmaSUG 2014 Proceedings, Paper SP02, 1-9.

Ranolazine Reduces The Late Recurrences Of Atrial Fibrillation. An Exploratory Analysis Of The Raffaello Study.

2014-SS-A-16181-AHA 2014 Chicago, USA.

Ranolazine in Atrial Fibrillation Following an electrical Cardioversion.

Oral lecture based on the late-breaking abstract no 14-LBT-9451-HRS, Heart Rhythm Conference 2014, San Francisco, USA

MEN1112, a Novel Humanized De-Fucosylated Monoclonal Antibody with High Affinity and Specificity for Bst1/CD157 Antigen and Enhanced CD16 Binding.

2014 56th ASH Annual Meeting and Exposition, S. Francisco (CA), Abstract Poster No. 3607.

Targeting and Depletion of Acute Myeloid Leukemia Blasts By MEN1112, a Novel Humanized Defucosylated Monoclonal Antibodies with Specificity for Bst1/CD157 Antigen.

2014 56th ASH Annual Meeting and Exposition, S. Francisco (CA), Abstract Poster No. 2235

Febuxostat head to head versus Allopurinol achieves a higher serum uric acid (sUA) control in Tumor Lysis Syndrome (TLS) prevention: results of FLORENCE pivotal study.

Poster presentation at MASCC/ISOO International Symposium on Supportive Care in Cancer; Miami, USA, June 26th-28th, 2014.

Prophylaxis with Febuxostat in comparison to Allopurinol reduces exposure to uric acid in patients at intermediate to high risk of tumor lysis syndrome: results of the Florence study.

19th Congress of the European Hematology Association, Milano, Italy, June 12th-15th, 2014. (Poster P586)

Decision Driven Factors for Allopurinol Dosage in Tumor Lysis Syndrome Prophylaxis: The European Experience of the Florence Pivotal Study.

Blood 2014; 124(21):5979

2014 ASCO Annual Meeting, A randomized double-blind phase III pivotal study of febuxostat (FEB) versus allopurinol (ALL) in the prevention of tumor lysis syndrome (TLS): Florence study.

J Clin Oncol 32:5s, 2014 (suppl; abstr 9641^)

DDW2014, Sa1080 Concordance Among Outcome Variables Assessing the Response to Treatment With Ibodutant in Irritable Bowel Syndrome With Diarrhea (IBS-D; the IRIS-2 Study).

Gastroenterology, May 2014 Volume 146, Issue 5, Supplement 1, Page S-194

Blood pressure control is similar in treated hypertensive patients with optimal or with high-normal albuminuria.

Am J Hypertens. 2014 Sep;27(9):1185-90.

Comparative Performance Assessment of Point-of-Care Testing Devices for Measuring Glucose and Ketones at the Patient Bedside.

J Diabetes Sci Technol. 2014 Dec 17. pii: 1932296814563351.

Hydrogen sulfide accounts for the peripheral vascular effects of zofenopril independently of ACE inhibition.

Cardiovasc Res. 2014 Apr 1;102(1):138-47

Stimulation of platelet nitric oxide production by nebivolol prevents thrombosis.

Arterioscler Thromb Vasc Biol. 2014 Apr;34(4):820-9

Comparison of frovatriptan plus dexketoprofen (25 mg or 37.5 mg) with frovatriptan alone in the treatment of migraine attacks with or without aura: a randomized study.

Cephalalgia. 2014 May;34(6):434-45

Dexketoprofen trometamol in the acute treatment of migraine attack: a phase II, randomized, double-blind, crossover, placebo-controlled, dose optimization study.

J Pain. 2014 Apr;15(4):388-94.

Zofenopril plus hydrochlorothiazide and irbesartan plus hydrochlorothiazide in previously treated and uncontrolled diabetic and non-diabetic essential hypertensive patients.

Adv Ther. 2014 Feb;31(2):217-33.

Efficacy of early vs. late use of frovatriptan combined with dexketoprofen vs. frovatriptan alone in the acute treatment of migraine attacks with or without aura.

Neurol Sci. 2014 May;35 Suppl 1:107-13

Efficacy of frovatriptan and other triptans in the treatment of acute migraine of normal weight and obese subjects: a review of randomized studies.

Neurol Sci. 2014 May;35 Suppl 1:115-9.

Inner and outer portions of colonic circular muscle: ultrastructural and immunohistochemical changes in rat chronically treated with otilonium bromide.

PLoS One. 2014 Aug 14;9(8)

Antagonism of bradykinin B2 receptor prevents inflammatory responses in human endothelial cells by quenching the NF-kB pathway activation.

PLoS One. 2014 Jan 2;9(1)

Concordance Among Outcome Variables Assessing the Response to Treatment With Ibodutant in Irritable Bowel Syndrome With Diarrhea (IBS-D; the IRIS-2 Study)

DDW Chicago, 2014

Frovatriptan and rizatriptan economic EVAluation: the FREEVA study.

J Headache Pain. 2013 Dec 11;14(1):96.

Cost-effectiveness of zofenopril in patients with left ventricular systolic dysfunction after acute myocardial infarction: a post hoc analysis of SMILE-4.

Clinicoecon Outcomes Res. 2013 Jul 8;5:317-25.

Efficacy of frovatriptan and other triptans in the treatment of acute migraine of hypertensive and normotensive subjects: a review of randomized studies.

Neurol Sci. 2013 May;34 Suppl 1:S87-91.

Frovatriptan vs. other triptans for the acute treatment of oral contraceptive-induced menstrual migraine: pooled analysis of three double-blind, randomized, crossover, multicenter studies.

Neurol Sci. 2013 May;34 Suppl 1:S83-6.

SMILE-4 Working Party. Zofenopril and ramipril and acetylsalicylic acid in postmyocardial infarction patients with left ventricular systolic dysfunction: a retrospective analysis in hypertensive patients of the SMILE-4 study.

J Hypertens. 2013 Jun;31(6):1256-64.

Angiotensin-converting-enzyme inhibition counteracts angiotensin II-mediated endothelial cell dysfunction by modulating the p38/SirT1 axis.

J Hypertens. 31:1972-1983, 2013.
doi:10.1097/HJH.0b013e3283638b32.PMID:23868084

Chronic treatment with otilonium bromide induces changes in L-type Ca²⁺ channel, tachykinins, and nitric oxide synthase expression in rat colon muscle coat.

Neurogastroenterol Motil. 2013, 25 (11): e728-39.

Beneficial effects of nebivolol and hydrochlorothiazide combination in spontaneously hypertensive rats.

J Int Med Res. 2013, 41:603-17

Comparison between the effects of lisinopril and losartan on the cougn reflex in anesthetized and awake rabbits.

J Physiol Pharmacol. 2013 Apr;64(2):201-10.

Characterization of ibodutant at NK2 receptor in human colon.

Eur. J. Pharmacol., 702: 32-37, 2013. doi: 10.1016/j.ejphar.2013.01.021. Epub 2013 Jan 29. PMID:23376417

Blockade of nociceptive sensory afferent activity of the rat knee joint by the bradykinin B2 receptor antagonist fasitibant.

Osteoarthritis & Cartilage 21: 1346-1354, 2013.

Characterization of a novel proinflammatory effect mediated by BK and the kinin B2 receptor in human preadipocytes.

Biochem. Pharmacol. 86(4): 508-520, 2013. doi: 10.1016/j.bcp.2013.06.005. Epub 2013 Jun 21. PMID:23796753

Comparison between oral and intra-articular antinociceptive effect of dexketoprofen and tramadol combination in monosodium iodoacetate-induced osteoarthritis in rats.

Eur. J. Pharmacol. 714: 346-351, 2013. doi: 10.1016/j.ejphar.2013.07.026. Epub 2013 Jul 23. PMID:23891968

Synovial fluid levels of bradykinin correlate with biochemical markers for cartilage degradation and inflammation in knee osteoarthritis.

Osteoarthritis Cartilage. 21(11): 1774-1780, 2013. doi: 10.1016/j.joca.2013.08.014. Epub 2013 Aug 11. PMID:23942063

Antagonist profile of ibodutant at the tachykinin NK2 receptor in guinea pig isolated bronchi.

Eur. J. Pharmacol. 720: 180-185, 2013

MicroRNA-130b promotes tumor development and is associated with poor prognosis in colorectal cancer.

Neoplasia. 2013 Oct;15(10):1218-31.

Benzofused hydroxamic acids: useful fragments for the preparation of histone deacetylase inhibitors. Part 1: hit identification.

Bioorg Med Chem Lett. 2013 Jul 15;23(14):4091-5. doi: 10.1016/j.bmcl.2013.05.053. Epub 2013 May 25. PMID:23768910

OC125, M11 and OV197 epitopes are not uniformly distributed in the tandem-repeat region of CA125 and require the entire SEA domain.

Dis Markers. 2013;34(4):257-67. doi: 10.3233/DMA-130968 PMID:23396293

(1R,2S,5R)-(–)-Menthyl(S)-2-(methoxycarbonyl)benzenesulfinate

Acta Cryst. 2013, E69, o731. doi: 10.1107/S1600536813009112. Print 2013 May 1.PMID:23723883

Minimizing the impact of time lag variability on accuracy evaluation of continuous glucose monitoring systems.

J Diabetes Sci Technol. 2012 Nov 1;6(6):1383-91.PMID:23294784.

N,N-Diethyl-2-(4-methyl-benzene-sulfonamido)-benzamide.

Acta Crystallogr Sect E Struct Rep Online. 2012 Nov 1;68(Pt 11):o3144-5. doi: 10.1107/S160053681204264X. Epub 2012 Oct 20. PMID:23284465.

Dibenzo[b,f][1,4]thia-zepin-11-yl-diethyl-amine.

Acta Crystallogr Sect E Struct Rep Online. 2012 Nov 1;68(Pt 11):o3133-4. doi: 10.1107/S1600536812042328. Epub 2012 Oct 13. PMID:23284456.

N-(2-Amino-5-chlorophenyl)-2-bromobenzenesulfonamide.

Acta Crystallogr Sect E Struct Rep Online 2012, E68, o3308–9.

GlucoMen Day continuous glucose monitoring system: a screening for enzymatic and electrochemical interferents.

J Diabetes Sci Technol. 2012 Sep 1;6(5):1172-81. PMID:23063044.

Set-up of a new series of HDAC inhibitors: the 5,11-dihydrodibenzo[b,e]azepin-6-ones as privileged structures.

Bioorg Med Chem Lett. 2012 Sep 1;22(17):5360-2. doi: 10.1016/j.bmcl.2012.07.067. Epub 2012 Jul 26. PMID:22877635.

SAHA/Vorinostat induces the expression of the CD137 receptor/ligand system and enhances apoptosis mediated by soluble CD137 receptor in a human breast cancer cell line.

Int J Oncol. 2012 Jul 13. doi: 10.3892/ijo.2012.1551. PMID:22797667.

Synthesis and biological evaluation of rebeccamycin analogues modified at the imide moiety.

Bioorg Med Chem Lett. 2012 Aug 1;22(15):5013-7. doi:10.1016/j.bmcl.2012.06.016. Epub 2012 Jun 15. PMID:22749423.

Fasitibant prevents the bradykinin and interleukin 1β synergism on prostaglandin E₂ release and cyclooxygenase 2 expression in human fibroblast-like synoviocytes.

Naunyn Schmiedebergs Arch Pharmacol. 2012 Aug;385(8):777-86. doi: 10.1007/s00210-012-0762-y. Epub 2012 May 26. PMID:22638761

Design and synthesis of novel sulfonamide-containing bradykinin hB(2) receptor antagonists. Synthesis and structure-relationships of α,α-tetrahydropyranylglycine.

Bioorg Med Chem. 2012 Mar 15;20(6):2091-100. doi: 10.1016/j.bmc.2012.01.036. Epub 2012 Jan 30. PMID:22342268.

Benefits from long-term treatment in irritable bowel syndrome.

Gastroenterol Res Pract. 2012;2012:936960. doi: 10.1155/2012/936960. Epub 2012 Jan 9. PMID:22272195.

Fasitibant chloride, a kinin B₂ receptor antagonist, and dexamethasone interact to inhibit carrageenan-induced inflammatory arthritis in rats.

Br J Pharmacol. 2012 Jun;166(4):1403-10. doi: 10.1111/j.1476-5381.2012.01861.x. PMID:22251015.

Tachykinin NK2 receptor antagonists. A patent review (2006 - 2010).

Expert Opin Ther Pat. 2012 Jan;22(1):57-77. doi: 10.1517/13543776.2012.645537. Epub 2011 Dec 9. Review. PMID:22149761

Efficacy of frovatriptan versus other triptans in the acute treatment of menstrual migraine: pooled analysis of three double-blind, randomized, crossover, multicenter studies.

Neurol Sci. 2012 May;33 Suppl 1:S65-9. doi: 10.1007/s10072-012-1044-7. PMID:22644174

Frovatriptan versus zolmitriptan for the acute treatment of migraine with aura: a subgroup analysis of a double-blind, randomized, multicenter, Italian study.

Neurol Sci. 2012 May;33 Suppl 1:S61-4. doi: 10.1007/s10072-012-1043-8. PMID:22644173.

4-N-Hydroxy-4-[1-(sulfonyl)piperidin-4-yl]-butyramides as HDAC inhibitors.

Bioorg Med Chem Lett. 2011 Nov 15;21(22):6767-9. Epub 2011 Sep 18. PMID: 21978679

Combined antihypertensive and cardioprotective effects of nebivolol and hydrochlorothiazide in spontaneous hypertensive rats.

Future Cardiol. 2011 Nov;7(6):757-63. PMID:22050062

Alkyl piperidine and piperazine hydroxamic acids as HDAC inhibitors.

Bioorg Med Chem Lett. 2011 Apr 15;21(8):2305-8. Epub 2011 Feb 26. PMID: 21420859

hNK2 receptor antagonists. The use of intramolecular hydrogen bonding to increase solubility and membrane permeability.

Bioorg Med Chem Lett. 2011 Mar 15;21(6):1807-9. Epub 2011 Feb 1. PMID: 21320781

Comparison of the molecular interactions of two antagonists, MEN16132 or icatibant, at the human kinin B₂ receptor.

Br J Pharmacol. 2011 Mar;162(5):1202-12. doi: 10.1111/j.1476-5381.2010.01133.x. PMID: 21108627

Bradykinin and B₂ receptor antagonism in rat and human articular chondrocytes..

Br J Pharmacol. 2011 Feb;162(3):611-22. doi: 10.1111/j.1476-5381.2010.01062.x. PMID: 20946124

Intestinal epithelial barrier dysfunction in disease and possible therapeutical interventions.

Curr Med Chem. 2011;18(3):398-426. Review. PMID: 21143118

Uncommon crystal motif of brucine in its diastereomeric salt with (11-oxo-11H-dibenzo[b,f][1,4] thiazepin-10-yl)-acetic acid. A case of possible crystallization-induced dynamic resolution

Cryst Eng Comm 2011, 13, 2310-2317.

Effect of otilonium bromide and ibodutant on the internalization of the NK2 receptor in human colon.

Neurogastroenterol Motil, 23, 96-102, 2011.

Manteinance therapy in ovarian cancer: molecular basic and therapeutic approach

Experimental and Therapeutic Medicine vol 2 (2): 173-180, 2011

A double-blind, randomized, multicenter, Italian study of frovatriptan versus rizatriptan for the acute treatment of migraine.

J Headache Pain. 2011;12(2):219-26

Efficacy of frovatriptan in the acute treatment of menstrually related migraine: analysis of a double-blind, randomized, cross-over, multicenter, Italian, comparative study versus rizatriptan.

J Headache Pain. 12:609-15, 2011.

Frovatriptan versus other triptans in the acute treatment of migraine: pooled analysis of three double-blind, randomized, cross-over, multicenter, Italian studies.

Frovatriptan versus other triptans in the acute treatment of migraine: pooled analysis of three double-blind, randomized, cross-over, multicenter, Italian studies.

Efficacy of frovatriptan in the acute treatment of menstrually related migraine: analysis of a double-blind, randomized, multicenter, Italian, comparative study versus zolmitriptan.

Neurol Sci. 2011;32 Suppl 1:S99-104.

hNK2 receptor antagonists. The use of intramolecular hydrogen bonding to increase solubility and membrane permeability.

Biorg. Med. Chem. Lett., 21 (2011) 1807–1809

Alkyl piperidine and piperazine hydroxamic acids as HDAC inhibitors.

Biorg. Med. Chem. Lett. 21 (2011) 2305–2308

4-N-Hydroxy-4-[1-(sulfonyl)piperidin-4-yl]-butyramides as HDAC inhibitors.

Biorg. Med. Chem. Lett. 21 (2011) 6767–6769

Randomized double-blind placebo-controlled international trial of abagovomab maintenance therapy in patients with advanced ovarian cancer after complete response to first-line chemotherapy: The Monoclonal Antibody Immunotherapy for Malignancies of the Ovary by Subcutaneous Abagovomab (MIMOSA) trial.

ASCO 2011 Oral presentation J Clin Oncol 29: 2011 (suppl; abstr LBA5002)

Abagovomab for Ovarian Cancer

Abagovomab for Ovarian Cancer Expert Opin, Biol Ther 2011

Maintenaince therapy in Ovarian cancer: Molecular basis and therapeutic approaches

Experimental and Therapeutic Medicine 10.3892/etm 2011

Frovatriptan versus zolmitriptan for the acute treatment of migraine: a double-blind, randomized, multicenter, Italian study.

Neurol Sci. 2010 31 Suppl 1:S51-4.

Anti-inflammatory synergy of MEN16132, a kinin B(2) receptor antagonist, and dexamethasone in carrageenan-induced knee joint arthritis in rats.

Br J Pharmacol. 2010 Dec;161(7):1616-27. doi: 10.1111/j.1476-5381.2010.00995.x. PMID:20726984

Differences between zofenopril and ramipril, two ACE inhibitors, on cough induced by citric acid in guinea pigs: role of bradykinin and PGE2.

Naunyn Schmiedebergs Arch Pharmacol. 2010 Dec;382(5-6):455-61. Epub 2010 Sep 17. PMID:20848272

Induction of a less aggressive phenotype in human colon carcinoma HCT116 cells by chronic exposure to HDAC inhibitor SAHA.

Oncol Rep. 2010 Nov;24(5):1249-55. PMID:20878117

Radioligand binding characterization of the bradykinin B(2) receptor in the rabbit and pig ileal smooth muscle.

Eur J Pharmacol. 2010 Jun 10;635(1-3):34-9. Epub 2010 Mar 20. PMID:20307535

Influence of tachykinin NK2 receptors on intestinal sensitivity and motility in newborn rats.

Neuropeptides. 2010 Jun;44(3):269-72. PMID:20137809

Structure-activity relationships of 6-methyl-benzo[b]thiophene-2-carboxylic acid (1-[(S)-1-benzyl-4-[4-(tetrahydropyran-4-ylmethyl)piperazin-1-yl]butylcarbamoyl]cyclopentyl)amide, potent antagonist of the neurokinin-2 receptor.

J Med Chem. 2010 May 27;53(10):4148-65. PMID:20408549

Tachykinin receptor assays.

Curr Protoc Pharmacol. 2010 Mar;Chapter 4:Unit 4.10. PMID:22294370

Modulation on C- and N-terminal moieties of a series of potent and selective linear tachykinin NK(2) receptor antagonists.

ChemMedChem. 2010 Jan;5(1):65-78. PMID:19957262

Evaluating the clinical accuracy of GlucoMen®Day: a novel microdialysis-based continuous glucose monitor.

J Diabetes Sci Technol. 2010 Sep 1;4(5):1182-92. PMID: 20920438

Interaction between double helix DNA fragments and the new antitumor agent sabarubicin, Men10755

Bioorg. Med. Chem. 18:1497-506, 2010.

Skeletal muscle sarcomeric protein oxidation in heart failure: can different beta-blockers prevent it to the same degree?

Int J Cardiol, 143, 192-199, 2010.

Efficacy and safety of olmesartan medoxomil 40 mg/hydrochlorothiazide 12.5 mg combination therapy versus olmesartan medoxomil 40 mg monotherapy in patients with moderate to severe hypertension: a randomized, double-blind, parallel-group, multicentre, multinational, phase III study.

Clin Drug Investig. 2010; 30(9), 581-97

T-type Ca2+ channel modulation by otilonium bromide.

Am J Physiol Gastrointest Liver Physiol 298, G706-G713, 2010.

Effects of zofenopril and ramipril on cough reflex responses in anaesthetized and awake rabbits.

Mutolo. J Cardiovasc Pharmacol Ther, 15, 384-392, 2010.

Antiproliferative and Differentiating Activities of a Novel Series of Histone Deacetylase Inhibitors.

ACS Med. Chem. Lett., 2010, 1 (8), pp 411–415

Pharmacokinetics and pharmacodynamics of ritodrine hydrochloride administered orally and intramuscularly to female healthy volunteers.

Arzneimittelforschung. 2010;60:510-8.

Frovatriptan versus zolmitriptan for the acute treatment of migraine: a double-blind, randomized, multicenter, Italian study.

Neurol Sci. 2010 31 Suppl 1:S51-4.

Mass Spectrometric Analysis of Deoxyinosines,In Mass Spectrometry of Nucleosides and Nucleic Acids

J. H. Banoub and Patrick A. Limbach, editors, CRC Press, 2010, 91-104

ALBATROSS – A Locally injected Bradykinin Antagonist for TReatment of OSteoarthritiS. An Ongoing Multicentre, Double Blind, Placebo Controlled, Phase-II Clinical Trial.

<p>Poster presentation at XXIII Congress of the Spanish Society of Clinical Pharmacology. e la (San Lorenzo del Escorial (Madrid). October 2010)</p>

Sabarubicin (SABA) in combination with cisplatin (DDP): Maximum tolerated dose (MTD) evaluation (phase I step) followed by a phase II step in patients (pts) with small cell lung cancer-extensive disease (SCLC-ED).

2010 ASCO Annual Meeting, Abstr.N.: 7048

Abagovomab maintenance therapy in patients with epithelial ovarian cancer after complete response (CR) postfirst- line chemotherapy (FLCT): Preliminary results of the randomized, double-blind, placebo-controlled, multicenter MIMOSA trial.

Journal of Clinical Oncology, 2010 ASCO Annual Meeting Proceedings (Post-Meeting Edition). Vol 28, No 15_suppl (May 20 Supplement), 2010: 5036

Multicentre, randomised, controlled study of the impact of continuous sub-cutaneous glucose monitoring (GlucoDay) on glycaemic control in type 1 and type 2 diabetes patients.

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Cyclic glycopeptidomimetics through a versatile sugar-based scaffold.

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J Pharmacol Exp Ther. 2009 May;329(2):486-95. Epub 2009 Feb 13. PubMed PMID: 19218528.

Role of calcitonin gene-related Peptide in gastric mucosal defence and healing.

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Structural characterization of the regioisomers of di(hydroxybutyl) ether by GC-EI MS and theoretical calculations.

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The chemistry of commercial continuous glucose monitors.

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Short-term effects on patient satisfaction of continuous glucose monitoring with the GlucoDay with real-time and retrospective access to glucose values: a crossover study.

Diabetes Technol Ther. 2009 May;11(5):275-81. PubMed PMID: 19425875.

Forces determining the adsorption of a monoclonal antibody onto an aluminium hydroxide adjuvant: influence of interstitial fluid components. Vaccine.

2009 Mar 13;27(12):1834-40. Epub 2009 Feb 4. PubMed PMID: 19200448.

Skeletal muscle proteins oxidation in chronic right heart failure in rats: Can different beta-blockers prevent it to the same degree?

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Chemically distinct HDAC inhibitors prevent adipose conversion of subcutaneous human white preadipocytes at an early stage of the differentiation program.

Exp Cell Res. 2009 Nov 15;315(19):3267-80. Epub 2009 Sep 18. PubMed PMID: 19766628.

Effect of intra-articular MEN16132, a kinin B2 receptor antagonist, on nociceptive response in monosodium iodoacetate-induced experimental osteoarthritis in rats.

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Pharmacological characterization of the bradykinin B2 receptor antagonist MEN16132 in rat in vitro bioassays.

Eur J Pharmacol. 2009 Aug 1;615(1-3):10-6. Epub 2009 May 13. PubMed PMID: 19445925.

New insight into the binding mode of peptide ligands at Urotensin-II receptor: structure-activity relationships study on P5U and urantide.

J Med Chem. 2009 Jul 9;52(13):3927-40. PubMed PMID: 19432421.

Spontaneous release of acetylcholine from autonomic nerves in the bladder.

Br J Pharmacol. 2009 Jun;157(4):607-19. Epub 2009 Apr 3. PubMed PMID: 19371347; PubMed Central PMCID: PMC2707973.

ACE inhibition and protection from doxorubicin-induced cardiotoxicity in the rat. Vascul Pharmacol.

2009 May-Jun;50(5-6):166-70. PubMed PMID:19344651.

Differential effect of ethanol and hydrogen peroxide on barrier function and prostaglandin E2 release in differentiated Caco-2 cells: selective prevention by growth factors.

J Pharm Sci. 2009 Feb;98(2):713-27. PubMed PMID: 18481313.

Excitatory and inhibitory urinary bladder reflexes induced by stimulation of cervicovaginal capsaicin-sensitive sensory fibers in rats.

Naunyn Schmiedebergs Arch Pharmacol. 2009 Feb;379(2):107-14. Epub 2008 Oct 7. PubMed PMID: 18839149.

Tricyclic structures in medicinal chemistry: an overview of their recent uses in non-CNS pathologies.

Mini Rev Med Chem. 2008 Dec;8(14):1464-84. Review. PubMed PMID: 19075805.

Cinnamic acids and mono-substituted benzoic acids as useful capping groups for the preparation of hNK2 receptor antagonists.

Bioorg Med Chem Lett. 2008 Aug 15;18(16):4705-7. Epub 2008 Jul 4. PubMed PMID: 18640835.

alpha,alpha-Cyclopentaneglycine dipeptides capped with biaryls as tachykinin NK(2) receptor antagonists.

ChemMedChem. 2008 Jul;3(7):1048-60. PubMed PMID: 18399514.

Histone deacetylase inhibitors: from bench to clinic.

J Med Chem. 2008 Mar 27;51(6):1505-29. Epub 2008 Feb 5. Review. Erratum in: J Med Chem. 2008 Jun 12;51(11):3330. PubMed PMID: 18247554.

Synthesis, biological evaluation, and molecular modeling studies of rebeccamycin analogues modified in the carbohydrate moiety.

ChemMedChem. 2008 Feb;3(2):266-79. PubMed PMID: 18157856.

Fragment-based approach to drug lead discovery: overview and advances in various techniques.

Drugs R D. 2008;9(4):217-27. Review. PubMed PMID: 18588353.

Clinical and pharmacologic study of the novel prodrug delimotecan (MEN 4901/T-0128) in patients with solid tumors.

Clin Cancer Res. 2008 Nov 15;14(22):7535-44. PubMed PMID: 19010872.

Systematic review of dexketoprofen in acute and chronic pain.

BMC Clin Pharmacol. 2008 Oct 31;8:11. Review. PubMed PMID: 18976451; PubMed Central PMCID: PMC2585070.

Proceedings of the VIth Menarini Autoimmunity Day.

November 18-19, 2007. Berlin Germany. Autoimmun Rev. 2008 Sep;7(8):585-650. PubMed PMID: 19058346.

Effect of HbS in the determination of HbA(2) with the Menarini HA-8160 analyzer and comparison with other instruments.

Int J Lab Hematol. 2008 Aug 6. [Epub ahead of print] PubMed PMID: 18691341.

Clinical use of real-time continuous glucose monitoring.

Curr Diabetes Rev. 2008 Aug;4(3):218-22. Review. PubMed PMID: 18690903.

ACE-inhibition ameliorates vascular reactivity and delays diabetes outcome in NOD mice.

Vascul Pharmacol. 2008 Aug-Sep;49(2-3):84-90. Epub 2008 Jun 13. PubMed PMID: 18606247.

FIGO Stage I endometrial carcinoma: evaluation of lung metastases and follow-up.

Eur J Gynaecol Oncol. 2008;29(1):65-6. PubMed PMID: 18386467.

Different effects of angiotensin converting enzyme inhibitors on endothelin-1 and nitric oxide balance in human vascular endothelial cells: evidence of an oxidant-sensitive pathway.

Mediators Inflamm. 2008;2008:305087. Epub 2008 Dec 1. PubMed PMID: 19079593; PubMed Central PMCID: PMC2592601.

Effects of nebivolol on endothelial gene expression during oxidative stress in human umbilical vein endothelial cells.

Mediators Inflamm. 2008;2008:367590. PubMed PMID: 18437228; PubMed Central PMCID: PMC2323596.

Spatial and temporal expression of tachykinins and NK1- and NK2-receptor gene during TNB induced colitis in rats.

Neuropeptides. 2008 Oct-Dec;42(5-6):663-70. Epub 2008 Aug 19. PubMed PMID: 18715640.

Antitumour effect of combination treatment with Sabarubicin (MEN 10755) and cis-platin (DDP) in human lung tumour xenograft.

Cancer Chemother Pharmacol. 2008 Sep;62(4):621-9. Epub 2007 Nov 24. PubMed PMID: 18038274.

Increased paracellular absorption by bile salts and P-glycoprotein stimulated efflux of otilonium bromide in Caco-2 cells monolayers as a model of intestinal barrier.

J Pharm Sci. 2008 Sep;97(9):4087-100. PubMed PMID: 18200532.

Tachykinin receptors and gastrointestinal motility: focus on humans.

Eur Rev Med Pharmacol Sci. 2008 Aug;12 Suppl 1:69-80. Review. PubMed PMID: 18924446.

Knee osteoarthritis: a role for bradykinin?

Inflamm Res. 2008 Aug;57(8):351-61. Review. PubMed PMID: 18787773.

MEN16132, a kinin B2 receptor antagonist, prevents the endogenous bradykinin effects in guinea-pig airways.

Eur J Pharmacol. 2008 Jan 28;579(1-3):350-6. Epub 2007 Oct 25. PubMed PMID: 18036587.

Alpha, alpha-Cyclic aminoacids as useful scaffolds for the preparation of hNK(2) receptor antagonists.

Bioorg Med Chem Lett. 2007 Sep 1;17(17):4841-4. Epub 2007 Jun 20. PubMed PMID: 17604625.

Fragment-based drug design: combining philosophy with technology.

Curr Opin Drug Discov Devel. 2007 Jul;10(4):422-9. Review. PubMed PMID: 17659483.

Effect of DL-nebivolol, its enantiomers and metabolites on the intracellular production of superoxide and nitric oxide in human endothelial cells.

Pharmacol Res. 2007 Apr;55(4):303-9. Epub 2007 Jan 12. PubMed PMID: 17280840.

Characterization of kinin receptors in human cultured detrusor smooth muscle cells.

Br J Pharmacol. 2007 Jan;150(2):192-9. Epub 2006 Dec 18. PubMed PMID: 17179953; PubMed Central PMCID: PMC2042898.

Bradykinin analogs containing the 4-amino-2-benzazepin-3-one scaffold at the C-terminus.

J Pept Sci. 2007 Mar;13(3):164-70. PubMed PMID: 17266049.

Algorithms from Continuous Monitoring Data: Assessment of Accuracy via Continuous Glucose Error-Grid Analysis.

J Diabetes Sci Technol. 2007 Sep 1;1(5):645-651. PubMed PMID: 19718282; PubMed Central PMCID: PMC2734107.

Glycemia prediction in critically ill patients using an adaptive modeling approach. J Diabetes Sci Technol.

2007 May;1(3):348-56. PubMed PMID: 19885089; PubMed Central PMCID: PMC2769583.