A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE SRL
Via Sette Santi, 1 50131 - Firenze (Firenze) Phone +39 055 56801 Fax +39 055 582771
Via Sette Santi, 1 50131 - Firenze (Firenze) Telefono +39 055 56801 Fax +39 055 582771
Everyday we put our values into action. 4 values, which have given life to Menarini and shaped its history.
Menarini is investing in advanced science and technology to develop a pipeline of new products that make a difference to the lives of patients affected by serious conditions.
MENARINI is a fully integrated privately owned pharma company with a long and successful heritage in strategic partnering across the globe. We have a profound know-how stemming from our strong R&D capabilities in key therapeutic areas, coupled with our excellence in commercial execution and our powerful direct presence on a global basis.
Our dedicated Corporate Business Development team is committed to assess and explore innovative new opportunities.
Donations of backpacks and cases for school, distribution of meals and medicines, promotion of sport, support for pregnant women and much more: being responsible for Menarini means transforming good intentions into concrete efforts. By helping others, we want to contribute to improve the world around us, starting with us.
What does it really make Menarini unique? The diversity and authenticity of our key resource - the People. Our cultural diversity helps us to drive innovation, adapt to business changes, face challenges, inspire ideas and develop our growth.
Menarini employees make all the difference, every day.
Ogni giorno mettiamo in pratica i nostri valori. 4 valori, che hanno dato vita a Menarini e ne hanno forgiato la storia.
Menarini investe continuamente nella scienza e nelle tecnologie all'avanguardia per lo sviluppo di una pipeline di nuovi prodotti che facciano la differenza nella vita dei pazienti affetti da gravi patologie.
Menarini è un’azienda privata completamente integrata con una lunga storia di collaborazioni di successo in tutto il Mondo. In Menarini abbiamo una conoscenza ed esperienza consolidata frutto della nostra capacità di Ricerca & Sviluppo nelle aree terapeutiche chiave, accompagnate da un’eccellente presenza capillare in tutto il Mondo.
Il nostro Team dedicato di Business Development è impegnato a valutare ed esplorare nuove opportunità innovative.
Dalla distribuzione di pasti e medicinali, dai kit per andare a scuola alla promozione dello sport all'aiuto per le donne in gravidanza: essere responsabili, per noi di Menarini, significa tradurre le buone intenzioni in sforzi concreti. Aiutando gli altri diamo il nostro contributo a migliorare il mondo che ci circonda, a partire da noi.
Che cosa rende davvero Menarini unica? La diversità ed autenticità del nostro valore più importante - le Persone. La nostra diversità culturale ci aiuta a guidare l'innovazione, ad adattarci ai cambiamenti di mercato, ad affrontare le sfide, ad ispirare idee e a promuovere la nostra crescita.
Chi lavora in Menarini fa la differenza, ogni giorno.
Glioblastoma multiforme (GBM) is the most frequent and aggressive brain tumor and remains uncurable1. The incidence of this tumor type is approximately six cases per 100.000 inpiduals worldwide and increases with age.2 The median age at diagnosis is 62 years and men are 1.6-fold more likely to be affected than women.1,2
The current treatment after diagnosis of GBM includes surgery followed by radiotherapy and chemotherapy. This approach can prolong survival but unfortunately patients will ultimately progress1. Currently, there is no standard of care for these patients and enrolment into a clinical trial is often the preferred treatment option.3 The prognosis for patients suffering from glioblastoma is poor: the overall five-year survival rate of 4-5% represents the lowest among all cancer types.4 There have been only modest improvements in the survival rates of the last decades and despite the initial aggressive treatment, the median overall survival for glioblastoma patients is only 15 months.4 This highlights the huge unmet need for a deeper understanding of the molecular mechanism driving tumorigenesis to develop more efficient innovative therapies.
GBM was the first cancer type that was systematically studied by genomic sequencing yielding in a better understanding of the underlying genomic alterations.5 The most common molecular changes affect EGFR signalling, PI3K signalling, the p53 pathway and the Rb pathway.5 However, targeting these pathways have failed to improve outcomes likely due to the fact that GBM growth is driven by a signalling network with functional redundancy that permits adaptation in response to targeted molecular treatments5,6. In addition, intratumoral heterogeneity with the presence of resistant cancer cell subclones and the presence of the blood-brain-barrier-representing a challenge for the delivery of therapeutic agents- may also lead to treatment failure1.
We at Menarini/ Stemline strive to further understand the underlying biology of this lethal disease to develop therapies that maintain the quality of life of patients suffering from GBM while changing the course of their disease.
References
1 Di Cintio et al, The Molecular and Microenvironmental Landscape of Glioblastomas: Implications for the Novel Treatment Choices.
2 Weller et al., EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood. Nature Reviews Clinical Oncology Vol 18, 171, March 2021
3 NCCN guidelines Central Nervous System Cancers (V1.2022)
4 Khabibov et al., Signaling pathways and therapeutic approaches in glioblastoma multiforme. International Journal of oncology 60:69, 2022
5 Brennan et al., The somatic genomic landscape of GBM. Cell 2013
6 Le Rhun et al., Molecular targeted therapy for glioblastoma.
Discover our stories from all over the world
Menarini � un�azienda privata completamente integrata con una lunga storia di collaborazioni di successo in tutto il Mondo. In Menarini abbiamo una conoscenza ed esperienza consolidata frutto della nostra capacità di Ricerca & Sviluppo nelle aree terapeutiche chiave, accompagnate da un�eccellente presenza capillare in tutto il Mondo.
Il nostro Team dedicato di Business Development � impegnato a valutare ed esplorare nuove opportunità innovative.
Scopri le nostre storie da tutto il mondo