Our site uses cookies to make navigation as functional as possible, including "third party" cookies and "profiling cookies" designed to tailor on-line contents to suit the preferences expressed while surfing the internet. Should you wish to receive more information, or deny your consent to some or all cookies, click here. If you proceed browsing this website, you will be consenting to the use of all cookies.

MEN1112

 

ONCOLOGY

Current development phase: Phase I

preclinical
phase i
phase ii
phase iii
preregistration

MEN1112 is the first monoclonal antibody to be developed in the collaboration between Menarini and OBT (Oxford BioTherapeutics).

MEN 1112 is a humanized de-fucosylated monoclonal IgG1 antibody that acts through an ADCC (Antibody-Dependent Cellular Toxicity) mechanism of action.




The target of MEN1112 is CD157, a protein over expressed in patient blasts who have acute myeloid leukemia (AML): data showing antitumor effects on cancer cell lines and on leukemic blasts from patients have been obtained.

The biotechenological process for the production of MEN1112 has been developed at Menarini Biotech in Pomezia. 

The first in human study in patients with relapsed/refractory acute myeloid leukemia (clinical study ARMY) is ongoing


 

VISIT OUR CLINICAL TRIALS DATABASE


AML

Acute myeloid  leukemia represents around 30% of total blood tumors with an incidence of 30.000 new patients every year in Europe and with 2.000 patients in Italy alone.
Chemotherapy is the current best available treatment, it eliminate blasts from bone marrow and from peripheral blood.
But still Acute myeloid leukemia has a poor outcome since only 24% of patients survive after 5 years.There is a strong medical need for new, more effective therapy.

THERAPEUTIC AREAS

Discover all of Menarini's products marketed in Italy. Read More »

DIAGNOSTICS

 

Advanced Technology

READ MORE »

THE MENARINI GROUP

Discover the leading Italian pharmaceutical company in the world. Read More »

MENARINI PILLS OF ART

Concession granted by Italian Ministry for Cultural Heritage and Activities Read more