A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE SRL
Via Sette Santi, 1 50131 - Firenze (Firenze) Phone +39 055 56801 Fax +39 055 582771
Via Sette Santi, 1 50131 - Firenze (Firenze) Telefono +39 055 56801 Fax +39 055 582771
Everyday we put our values into action. 4 values, which have given life to Menarini and shaped its history.
Menarini is investing in advanced science and technology to develop a pipeline of new products that make a difference to the lives of patients affected by serious conditions.
MENARINI is a fully integrated privately owned pharma company with a long and successful heritage in strategic partnering across the globe. We have a profound know-how stemming from our strong R&D capabilities in key therapeutic areas, coupled with our excellence in commercial execution and our powerful direct presence on a global basis.
Our dedicated Corporate Business Development team is committed to assess and explore innovative new opportunities.
Donations of backpacks and cases for school, distribution of meals and medicines, promotion of sport, support for pregnant women and much more: being responsible for Menarini means transforming good intentions into concrete efforts. By helping others, we want to contribute to improve the world around us, starting with us.
What does it really make Menarini unique? The diversity and authenticity of our key resource - the People. Our cultural diversity helps us to drive innovation, adapt to business changes, face challenges, inspire ideas and develop our growth.
Menarini employees make all the difference, every day.
Ogni giorno mettiamo in pratica i nostri valori. 4 valori, che hanno dato vita a Menarini e ne hanno forgiato la storia.
Menarini investe continuamente nella scienza e nelle tecnologie all'avanguardia per lo sviluppo di una pipeline di nuovi prodotti che facciano la differenza nella vita dei pazienti affetti da gravi patologie.
Menarini è un’azienda privata completamente integrata con una lunga storia di collaborazioni di successo in tutto il Mondo. In Menarini abbiamo una conoscenza ed esperienza consolidata frutto della nostra capacità di Ricerca & Sviluppo nelle aree terapeutiche chiave, accompagnate da un’eccellente presenza capillare in tutto il Mondo.
Il nostro Team dedicato di Business Development è impegnato a valutare ed esplorare nuove opportunità innovative.
Dalla distribuzione di pasti e medicinali, dai kit per andare a scuola alla promozione dello sport all'aiuto per le donne in gravidanza: essere responsabili, per noi di Menarini, significa tradurre le buone intenzioni in sforzi concreti. Aiutando gli altri diamo il nostro contributo a migliorare il mondo che ci circonda, a partire da noi.
Che cosa rende davvero Menarini unica? La diversità ed autenticità del nostro valore più importante - le Persone. La nostra diversità culturale ci aiuta a guidare l'innovazione, ad adattarci ai cambiamenti di mercato, ad affrontare le sfide, ad ispirare idee e a promuovere la nostra crescita.
Chi lavora in Menarini fa la differenza, ogni giorno.
2018 - 12 - 20
The Menarini Group has recently reached an agreement with Melinta Therapeutics to commercialize meropenem/vaborbactam in Europe, Asia-Pacific and CIS.
As highlighted by the Group’s General Manager, Pio Mei, “The meropenem/vaborbactam European approval is the first great achievement coming from our partnership with Melinta. It confirms Menarini’s commitment in the Infectious Disease Area and its involvement in the fight against the antimicrobial resistance threat, a highly unmet need.”
Meropenem/vaborbactam was initially approved by the FDA for complicated urinary tract infections, including pyelonephritis, in adult patients on the basis of the pivotal TANGO I trial.
The European approval relied also on the results of the TANGO II trial, the largest trial conducted so far in patients with Carbapenem-Resistant Enterobacteriaceae (CRE) infections. According to the trial’s results, the range of clinical indications for meropenem/vaborbactam has been expanded by adding to cUTI (including pyelonephritis) also hospital-acquired/ventilator-associated bacterial pneumonia, complicated intra-abdominal infections and bacteremia associated with these previous infections.
Vaborbactam is a potent first-in-class inhibitor of class A (including the KPC, Klebsiella pneumoniae carbapenemase) and class C beta-lactamases, and it protects meropenem from degradation by serine carbapenemases, restoring its activity against carbapenem-resistant strains.
In TANGO II, meropenem/vaborbactam as intravenous monotherapy, compared with the “best available treatment,” was associated with increased clinical cure, reduced mortality, and lower treatment-related AEs (e.g. nephrotoxicity). The increased cure rate was statistically significant also in immunocompromised patients, a group usually excluded from clinical trials.
The spread of carbapenem resistance in Gram negative bacteria represents a serious and growing threat worldwide as identified by the WHO and CDC. CRE infections, because of limited therapeutic options, are associated with high rates of mortality as well as increased length of hospital stay and costs. According to the most recent data from the European Antimicrobial Resistance Surveillance Network (EARS-Net), the prevalence of invasive CRE isolates reaches worrisome levels particularly in some European countries. Romania, Italy and Greece show a rate of 31%, 34% and 67%, respectively, for invasive Klebsiella pneumoniae isolates (from blood and cerebrospinal fluid) with resistance to carbapenems.
In this context, meropenem/vaborbactam appears to be a potential game changer in the fight against difficult-to-treat Gram negative infections, satisfying an important medical issue linked to antibiotic-resistant Enterobacteriaceae.
About the Menarini Group
The Menarini Group is an Italian pharmaceutical company with a turnover of 3.6 billion Euro and more than 17,000 employees. With 16 manufacturing sites and 7 R&D centers, Menarini has a capillary presence in 136 countries.
www.menarini.com
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Menarini � un�azienda privata completamente integrata con una lunga storia di collaborazioni di successo in tutto il Mondo. In Menarini abbiamo una conoscenza ed esperienza consolidata frutto della nostra capacità di Ricerca & Sviluppo nelle aree terapeutiche chiave, accompagnate da un�eccellente presenza capillare in tutto il Mondo.
Il nostro Team dedicato di Business Development � impegnato a valutare ed esplorare nuove opportunità innovative.
Scopri le nostre storie da tutto il mondo