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Menarini is investing in advanced science and technology to develop a pipeline of new products that make a difference to the lives of patients affected by serious conditions.

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MENARINI is a fully integrated privately owned pharma company with a long and successful heritage in strategic partnering across the globe. We have a profound know-how stemming from our strong R&D capabilities in key therapeutic areas, coupled with our excellence in commercial execution and our powerful direct presence on a global basis.

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Our dedicated Corporate Business Development team is committed to assess and explore innovative new opportunities.

 

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Donations of backpacks and cases for school, distribution of meals and medicines, promotion of sport, support for pregnant women and much more: being responsible for Menarini means transforming good intentions into concrete efforts. By helping others, we want to contribute to improve the world around us, starting with us.

Our Values

Everyday we put our values into action. 4 values, which have given life to Menarini and shaped its history.

 

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What does it really make Menarini unique? The diversity and authenticity of our key resource - the People.
Our cultural diversity helps us to drive innovation, adapt to business changes, face challenges, inspire ideas and develop our growth.

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Menarini employees make all the difference, every day.

 

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News

2020-07-02

Menarini Ricerche Announces C-PRECISE-01, a New Phase Ib/II Trial of MEN1611 in Colorectal Cancer

Pomezia, Italy, July 2nd, 2020 – Menarini Ricerche, the R&D division of the Menarini Group, announced today that it plans to launch in the second-half of 2020 a new phase Ib/II trial of MEN1611, a potent and selective orally available phosphatidylinositol 3-kinase inhibitor currently in development for the treatment of breast cancer. The new study, called C-PRECISE-01, will evaluate MEN1611 and cetuximab in patients with PIK3CA mutated, RAS and RAF wild-type metastatic colorectal cancer (mCRC), failing irinotecan, oxaliplatin, 5-FU and anti-EGFR containing regimens.

The study design will be presented at the virtual 2020 ESMO World Congress on Gastrointestinal Cancer on July [1-4], with the e-poster entitled “C-PRECISE-01 Study: a phase Ib/II trial of MEN1611, a PI3K inhibitor, and cetuximab in patients with PIK3CA mutated metastatic colorectal cancer failing irinotecan, oxaliplatin, 5-FU and anti-EGFR containing regimens”.

MEN1611 is an oral PI3K inhibitor active on the p110α, β and γ isoforms, while sparing the δ. Preclinical and clinical evidence supports the development of MEN1611 in combination with other agents in the context of solid tumors. The presence of PIK3CA mutations in mCRC has been reported to correlate with a negative prediction of response to anti-EGFR treatment, making PI3K an attractive therapeutic target. The primary objective of the C-PRECISE-01 study is to determine the combination RP2D and to assess the antitumor activity of MEN1611. Secondary objectives will include the assessment of safety, tolerability and pharmacokinetics profile of MEN1611 in combination with cetuximab.

 

Andrea Pellacani, General Manager of Menarini Ricerche, commented: “Colorectal cancer is among the most prevalent malignancies in the world, and there is an urgent need to discover new therapeutic options to help CRC patients, especially those with metastatic lesions. The initiation of the C-PRECISE-01 trial will give us the possibility to investigate the potential of MEN1611 in a disease with high medical need, where PIK3CA represents a suitable therapeutic target. This confirms our commitment to advance precision oncology and develop effective healthcare solutions that can make the difference for cancer patients”.

 
 
Tags: Cancer

Fraud Warning Disclaimer

Please be aware that certain individuals might approach you by falsely presenting themselves as our employees, affiliates, agents or representatives. Under this false pretense, they might try to gain access to your personal information or to acquire money or other valuables from you by offering fictitious employment opportunities or by claiming that they are contacting you on our behalf. The contacting individual or organisation may, for example, claim that we can guarantee your employment if you pay them a certain amount of money. Such fraudulent offers and claims are usually received via email, the internet, text message, phone, etc. These claims and offers are fraudulent and invalid and you are strongly advised to exercise great caution when you receive such an offer of employment or notice. Be very mindful of such scams.Below we list some of the features such an offer or claim may have:

Below we list some of the features such an offer or claim may have:

• It may propose a phone or instant message program interview and/or money as a precondition for hiring You may be requested to disclose private, sensitive or confidential information

• You may be told that you were contacted in such a manner because it is a matter of urgency

Such an offer or claim will probably be in the form of an email sent from a fake email address or from a free email address and not from an official Menarini Group email address. Please take extra caution while examining such an email address, as the perpetrators may misspell an official Menarini Group email address and use a slightly modified version of an official Menarini Group email address.

Please note that you will never receive a fraudulent employment offer or any other similar claim from us, because we do not provide any recruitment services. Moreover, we will never ask you for money in exchange for employment opportunities or other similar services. Any such offer of employment or any other service in exchange for fees that claims to be from us is deceitful and part of a fraud.

Criminal and/or civil liabilities may arise from such actions and we intend to cooperate with competent law enforcement agencies. Accordingly, we would ask you to immediately get in touch with us upon receiving a suspicious offer or claim and additionally notify the police or other competent authority.

In any case, please disregard any written or oral request related to a job offer or an interview that you believe is or might be fraudulent or suspicious.

Please note that under no circumstances shall Menarini Group be held liable or responsible for any claims, losses, damages, expenses or other inconvenience resulting from or in any way connected to the actions of these imposters.