A. MENARINI INDUSTRIE FARMACEUTICHE RIUNITE SRL
Via Sette Santi, 1 50131 - Firenze (Firenze) Phone +39 055 56801 Fax +39 055 582771
Via Sette Santi, 1 50131 - Firenze (Firenze) Telefono +39 055 56801 Fax +39 055 582771
Everyday we put our values into action. 4 values, which have given life to Menarini and shaped its history.
Menarini is investing in advanced science and technology to develop a pipeline of new products that make a difference to the lives of patients affected by serious conditions.
MENARINI is a fully integrated privately owned pharma company with a long and successful heritage in strategic partnering across the globe. We have a profound know-how stemming from our strong R&D capabilities in key therapeutic areas, coupled with our excellence in commercial execution and our powerful direct presence on a global basis.
Our dedicated Corporate Business Development team is committed to assess and explore innovative new opportunities.
Donations of backpacks and cases for school, distribution of meals and medicines, promotion of sport, support for pregnant women and much more: being responsible for Menarini means transforming good intentions into concrete efforts. By helping others, we want to contribute to improve the world around us, starting with us.
What does it really make Menarini unique? The diversity and authenticity of our key resource - the People. Our cultural diversity helps us to drive innovation, adapt to business changes, face challenges, inspire ideas and develop our growth.
Menarini employees make all the difference, every day.
Ogni giorno mettiamo in pratica i nostri valori. 4 valori, che hanno dato vita a Menarini e ne hanno forgiato la storia.
Menarini investe continuamente nella scienza e nelle tecnologie all'avanguardia per lo sviluppo di una pipeline di nuovi prodotti che facciano la differenza nella vita dei pazienti affetti da gravi patologie.
Menarini è un’azienda privata completamente integrata con una lunga storia di collaborazioni di successo in tutto il Mondo. In Menarini abbiamo una conoscenza ed esperienza consolidata frutto della nostra capacità di Ricerca & Sviluppo nelle aree terapeutiche chiave, accompagnate da un’eccellente presenza capillare in tutto il Mondo.
Il nostro Team dedicato di Business Development è impegnato a valutare ed esplorare nuove opportunità innovative.
Dalla distribuzione di pasti e medicinali, dai kit per andare a scuola alla promozione dello sport all'aiuto per le donne in gravidanza: essere responsabili, per noi di Menarini, significa tradurre le buone intenzioni in sforzi concreti. Aiutando gli altri diamo il nostro contributo a migliorare il mondo che ci circonda, a partire da noi.
Che cosa rende davvero Menarini unica? La diversità ed autenticità del nostro valore più importante - le Persone. La nostra diversità culturale ci aiuta a guidare l'innovazione, ad adattarci ai cambiamenti di mercato, ad affrontare le sfide, ad ispirare idee e a promuovere la nostra crescita.
Chi lavora in Menarini fa la differenza, ogni giorno.
2020 - 4 - 29
Enumeration of Circulating Endothelial Cells (CECs) with CELLSEARCH platform may offer a new tool for investigating the role of the damaged endothelium in SARS-CoV-2 infection and clinical manifestation. Bologna, Italy -- Menarini Silicon Biosystems, a global leader in liquid biopsy and rare cells technologies, today announces that it is exploring the possible use of its proprietary CELLSEARCH technology to study the progression of COVID-19 disease --and to potentially identify patients who may be at risk of developing the most severe complications of the disease. “In this global health crisis we are applying all our resources, in terms of technology and know-how, to provide to researchers and clinicians new instruments to better understand COVID-19 pathogenesis,” said Fabio Piazzalunga, President of Menarini Silicon Biosystems. When the novel coronavirus, SARS-CoV-2, infects the lungs, it directly targets both components of the lung epithelial-endothelial barrier, through a receptor called angiotensin‐converting enzyme 2 (ACE2). That can damage the cells lining the inner surface of the blood vessels in the lungs, or the endothelium. The damaged endothelium then may play a central role in amplifying and perpetuating the pro-inflammatory cascade that can lead to the most severe COVID-19 complication, known as Acute Respiratory Distress Syndrome (ARDS). Many studies have shown that a very specific and sensitive marker of endothelial damage in a variety of diseases, including cardiovascular events, is the number of endothelial cells that are circulating in the bloodstream. Menarini’s CELLSEARCH technology is able to automatically capture and precisely count these Circulating Endothelial Cells (CECs). As a result, the technology could represent an important new tool for investigating the role of the damaged endothelium in COVID-19 clinical manifestation. In particular, an increase in CEC count may predict the onset and worsening of respiratory distress and cardiovascular events due to the pro-inflammatory cascade. “Given the mounting evidence of the important involvement of the cardiovascular system in the most severe forms of COVID-19, we are now offering an accurate and validated system to study the role of the endothelium during SARS-CoV-2 infection through the analysis of CECs,” explained Piazzalunga. The CELLSEARCH Circulating Endothelial Cell Kit*, produced in the company’s manufacturing facility in Huntingdon Valley (US) and used in conjunction with the CELLSEARCH platform, enumerates CECs by immuno-magnetically capturing CD146-positive cells from whole blood. The technology has been extensively validated in different settings, such as cardiovascular, neoplastic and autoimmune diseases, as reported in 30 peer-reviewed papers. * For Research Use Only. Not for use in diagnostic procedures. The performance characteristics, safety, and effectiveness have not been established and are not cleared or approved by the FDA.
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Menarini � un�azienda privata completamente integrata con una lunga storia di collaborazioni di successo in tutto il Mondo. In Menarini abbiamo una conoscenza ed esperienza consolidata frutto della nostra capacità di Ricerca & Sviluppo nelle aree terapeutiche chiave, accompagnate da un�eccellente presenza capillare in tutto il Mondo.
Il nostro Team dedicato di Business Development � impegnato a valutare ed esplorare nuove opportunità innovative.
Scopri le nostre storie da tutto il mondo