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DEXKETOPROFEN + TRAMADOL

NSAID + weak opioid

DOLORE

CURRENT DEVELOPMENT PHASE: Acute pain

preclinicl
phase i
phase ii
phase iii
pre-registration
post-registration

The project objective was the development of a fixed combination of dexketoprofen (a product of Menarini’s research) and tramadol for the indication of "acute pain with a moderate to severe intensity", such as post-operative pain (hysterectomy, hip replacement, extraction of third molar, etc.).

As a result, coated tables are onto the market in EU and oral granules have been approved by EMA.

The combination of these two drugs belonging to different classes with different pharmacokinetic and pharmacodynamic characteristics results in a superior analgesic effect with the reduction of the tramadol dose.

In a recent clinical study, the fixed combination tramadol/dexketoprofen demonstrated a superior analgesic efficacy in comparison to the fixed combination of tramadol/paracetamol.

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